Tocilizumab相关论文
葡萄膜炎是幼年特发性关节炎（JIA）最常见的关节外表现，多表现为反复发作的慢性前葡萄膜炎，其发病隐匿、并发症多等特点可导致患者眼部......
Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, mult
Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiv......
由罗氏(Roche)旗下基因泰克(Genentech)公司开发的单克隆抗体tocilizumab(商品名为Actemra)于近期获FDA批准,用于治疗活动期全身型......
Tocilizumab in patients with moderate or severe COVID-19:a randomized,controlled,open-label,multicen
Tocilizumab has been reported to attenuate the “cytokine storm” in COVID-19 patients.We attempted to verify the effect......
BACKGROUNDThe majority of patients with coronavirus disease 2019 (COVID-19) have goodprognoses, but some develop a criti......
据官方披露的上市后报告称,由罗氏旗下的Chugai公司研发并在日本上市的类风湿性关节炎(RA)一线治疗药单克隆抗体tocilizumab(商品......
Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage: Co
COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has produced a serious emergency for global public healt......
Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematolo......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
由罗氏(Roche)旗下基因泰克(Genentech)公司开发的单克隆抗体tocilizumab(商品名为Aetemra)于近期获FDA批准,用于治疗活动期全身型......
目的 评价白介素6受体抑制剂(Tocilizumab,MRA)治疗类风湿关节炎的疗效和不良反应.资料来源:检索PubMed、OVID、Cochrane Library......
Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage:Com
COVID-19,a disease caused by the novel coronavirus SARS-Co V-2,has produced a serious emergency for global public health......
目的探讨托珠单抗对心衰大鼠辅助性T细胞17(Th17)介导的心肌炎症反应的影响及对心功能的保护作用。方法利用冠状动脉左前降支结扎......
目的：观察托珠单抗（tocilizumab,TCZ）治疗重症活动性类风湿关节炎（rheumatoid arthritis,RA）的临床疗效及不良反应。方法：12例重症活动性......
目的探讨托珠单抗(tocilizumab,TCZ)治疗重症和(或)难治性血管白塞病(Behcet’s disease,BD)的疗效和安全性。方法回顾性分析北京......
近日，一名67岁的女性患者在使用罗氏公司治疗风湿性关节炎（RA）的单克隆抗体tocilizumab时出现致死性过敏反应。Tocilizumab（商品名：Acte......
目的:研究托珠单抗联合改善病情抗风湿药(DMARDs)治疗中重度活动性类风湿关节炎(RA)12周临床疗效及不良反应。方法:20例中重度活动......
目的探讨托珠单抗对类风湿关节炎合并骨质疏松患者骨代谢的影响。方法 30例类风湿关节炎患者,在第0周、第4周、第8周分别予以托珠......
目的探讨托珠单抗治疗类风湿关节炎(RA)的临床疗效并评价其安全性。方法选取该院2015年3月—2016年3月风湿科收治的70例RA患者为研......
目的随访观察应用托珠单抗(TCZ)与糖皮质激素(GC)治疗类风湿关节炎(RA)的疗效与安全性。方法选择2014年11月至2017年7月住院治疗的......
目的比较托珠单抗与英夫利西单抗在治疗类风湿关节炎患者的疗效差异性。方法选取类风湿关节炎患者60例,分为托珠单抗组（30例）、英夫......
Remission of arthritis but persistent cutaneous lesions following tocilizumab treatment in a RA-pati
Modulation of the interleukin-6 pathway with tocilizumab has been demonstrated to be highly effective in substantial num......
Remission of arthritis but persistent cutaneous lesions following tocilizumab treatment in a RA-pati
Modulation of the interleukin-6 pathway with tocilizumab has been demonstrated to be highly effective in substantial num......
目的探讨中性粒细胞／淋巴细胞比值（NLR）在托珠单抗（TCZ）治疗类风湿关节炎（RA）疗效评估中的价值。方法根据治疗后疾病活动度情况，将接受TCZ......
Objective:To study the clinical efficacy of tocilizumab combined with leflunomide in the treatment of rheumatoid arthrit......
Castleman病（CD）是一种少见的淋巴组织增殖性疾病,病因可能与病毒感染、细胞因子调节异常和血管增生等有关。近年研究发现,人类疱疹......
Risk of hepatitis B virus reactivation in rheumatoidarthritis patients undergoing biologic treatment
Hepatitis B virus （HBV） reactivation in rheumatoidarthritis （RA） patients undergoing biological therapy isnot infrequent. Th......
目的观察tocilizumab对肺动脉高压大鼠白细胞介素-6（IL-6）和survivin的表达水平的影响。方法通过腹腔注射野百合碱诱导建立肺动脉高......
研究背景类风湿关节炎(rheumatoid arthritis,RA)是一种慢性系统性自身免疫性疾病,累及全身多器官及组织,全球成年人发病率约为l%......
BACKGROUND The main pathophysiological basis of coronavirus disease 2019(COVID-19)causing respiratory failure is a cytok......
Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome corona......
据官方披露的上市后报告称，由罗氏旗下的Chugai公司研发并在13本上市的类风湿性关节炎（RA）一线治疗药单克隆抗体tocilizumab（商品名：Act......
单克隆抗体是继疫苗和重组蛋白后最重要的一类生物制剂,已成功应用于治疗自身免疫性疾病和肿瘤等疾病中。单抗药物经历了从鼠源单......
Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthri
To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (......
Takayasu arteritis is a large vessel vasculitis of the young women with giant cells and granuloma formation. The diagnos......
The pandemic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has garnered the attention of scientis......
<正>美国FDA于2017年5月22日批准Hoffman La Roche公司生产的Actemra(tocilizumab)皮下注射剂用于治疗成人巨细胞动脉炎(giant cel......
研究背景和目的:随着人口老龄化、环境恶化等因素,全球器官衰竭的患者发病率逐年上升。同种异体移植是终末期器官衰竭的最有效的治......
美国食品药品管理局(FDA)批准Tocilizumab用于治疗类风湿性关节炎,该药适用于使用其他已获批的治疗药物无效的成年中重度类风湿性......
期刊
[目的]IL一6是一种多效性的细胞因子，与动咏粥样硬化的发生发展密切相关。为了验证在慢性炎症过程中，IL一6对动咏粥样硬化发生发展的......
IL-6是一种多效性前炎症细胞因子,有多种生物活性,包括介导炎症反应,免疫反应等。IL-6在许多炎症性疾病中高表达,如RA,SLE,Crohn’......
期刊
目的脑胶质瘤(Glioma)是颅内常见的恶性肿瘤之一,发病率呈逐年上升趋势,且因易复发,病人死亡率高。脑胶质瘤干细胞(Glioma stem ce......
